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本人从事半个世纪生物医学，工作单位：兰州生物制品研究所，退休后和患老年痴呆症老伴相依为命，和电脑为伴，漫游地球村，网页：关爱生命 生物技术研究所：http://liuyr.blog.bokee.net/
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- 刘永润
- 地区：兰州
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阿兹海默症的鼻腔喷雾疫苗？——老白龙马 译
An Alzheimer's Vaccine in a Nasal Spray?
ScienceDaily (Mar. 8, 2011) — One in eight Americans will fall prey to Alzheimer's disease at some point in their life, current statistics say. Because Alzheimer's is associated with vascular damage in the brain, many of them will succumb through a painful and potentially fatal stroke.
But researchers led by Dr. Dan Frenkel of Tel Aviv University's Department of Neurobiology at the George S. Wise Faculty of Life Sciences are working on a nasally-delivered 2-in-1 vaccine that promises to protect against both Alzheimer's and stroke. The new vaccine repairs vascular damage in the brain by rounding up "troops" from the body's own immune system.
And in addition to its prophylactic effect, it can work even when Alzheimer's symptoms are already present. The research on this new technology was recently accepted for publication in the journal Neurobiology of Aging.
A natural way to fight Alzheimer's
"Using part of a drug that was previously tested as an influenza drug, we've managed to successfully induce an immune response against amyloid proteins in the blood vessels," says Dr. Frenkel, who collaborated on this project with Prof. Howard L. Weiner of Brigham and Women's Hospital, Harvard Medical School. "In early pre-clinical studies, we've found it can prevent both brain tissue damage and restore cognitive impairment," he adds.
Modifying a vaccine technology owned by Glaxo Smith Kline, a multinational drug company, Tel Aviv University's new therapeutic approach activates a natural mechanism in our bodies that fights against vascular damage in the brain.
The vaccine, Dr. Frenkel explains, activates macrophages -- large proteins in the body that swallow foreign antigens. When the vaccine activates large numbers of these macrophages, they clear away the damaging build-up of waxy amyloid proteins in our brain's vascular system.
Animal models showed that once these proteins are cleared from the brain, further damage can be prevented, and existing damage due to a previous stroke can be repaired.
A new road to an Alzheimer's cure?
Could the breakthrough lead to both a vaccine and a long-sought cure for Alzheimer's disease? "It appears that this could be the case," says Dr. Frenkel, who worked on the study with his doctoral student Veronica Lifshitz and master degree students Ronen Weiss and Tali Benromano. "We've found a way to use the immune response stimulated by this drug to prevent hemorrhagic strokes which lead to permanent brain damage," he says.
In the animal models in mice, Dr. Frenkel's team worked with MRI specialist Prof. Yaniv Assaf and his Ph.D. student Tamar Blumenfeld-Katzir of Tel Aviv University's Department of Neurobiology and then with "object recognition" experiments, testing their cognitive functioning both before and after administration of the vaccine. MRI screenings confirmed that, after the vaccine was administered, further vascular damage was prevented, and the object recognition experiments indicated that those animals treated with the new vaccine returned to normal behavior.
Dr. Frenkel believes that this approach, when applied to a human test population, will be able to prevent the downward health spiral of Alzheimer's and dementia. The vaccine could be given to people who are at risk, those who show very early symptoms of these diseases, and those who have already suffered strokes to repair any vascular damage.
So far the vaccine has shown no signs of toxicity in animal models. Dr. Frenkel is hopeful that this new approach could lead to a cure, or at least an effective treatment, for the vascular dementia found in 80% of all people with Alzheimer's.
阿兹海默症的鼻腔喷雾疫苗？——老白龙马 译
老白龙马点评：
阿兹海默症又称老年痴呆症，是老年病和慢性病之一，在医学界还是绝症，不可逆转的，这里报告的是免疫疗法，激活巨噬细胞，是非特异免疫反应，免疫调节，点亮生命之灯，是可以减轻或缓解老年痴呆症的许多症状的。
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科学日报（2011年,3月8日）-当前统计表明有1/8的美国人在他们的一生的某个时候会患阿兹海默症。因为阿兹海默症常伴有脑血管损害，病人多饱受病痛折磨和甚至是致命的中风。
但特拉维夫大学神经生物学系的丹·弗仑克尔博士领导研究者在乔治·S生命科学智慧系进行经鼻2合1疫苗的工作，有望预防阿兹海默症和栓塞。新疫苗通过身体自身免疫系统派遣“部队”在脑中修复脉管损伤。
此外它还有预防作用，它甚至能对早已存在的阿兹海默症症状起作用。这新技术研究新近在衰老神经生物学杂志公布。
战胜阿兹海默症的天然之法
“用一药物的部分，以前作为一种流感药物测试过，我们致力对血管淀粉样蛋白成功诱生免疫应答，”弗仑克尔博士说，这项目与布里格姆霍华德 L.温纳教授和哈佛大学医学院妇科医院合作。“早在临床前试验，我们就发现它能预防脑组织损伤和恢复认知障碍，”他说。
跨国药物公司葛兰素史克拥有一种修饰疫苗技艺，特拉维夫大学有一种新治疗方法激活我们身体的天然机制，去战胜脑血管损伤。
这种疫苗，弗仑克尔博士解释道，能激活大量巨噬细胞，去清除堆积在我们脑血管系统中引起损害的腊状淀粉样蛋白。
动物模型表明，这些蛋白一经从脑中清除掉，就能阻止进一步损害，和由以前血管梗阻引起的损害也能被修复。
治愈阿兹海默症的一种新方法？
这种疫苗对永久治愈阿兹海默症是一种突破？“它表明，果然如此”弗仑克尔博士说，与他的博士生维罗妮卡利弗希兹和硕士生罗奈维斯和塔利贝鲁玛努一起研究。“我们发现应用这种药物刺激免疫应答的方法以防止能够导致永久脑损伤的出血性中风”他说。
在小鼠动物模型，弗仑克尔博士小组与特拉维夫大学神经生物系MRI（核磁共振成像）专家雅尼夫·亚瑟夫教授和他化学博士生他马布鲁门费德-卡特泽一起工作，他们用“标的物识别”试验，测试它们在疫苗应用之前和之后的识别功能。MRI放映证实，在使用疫苗之后，能阻止脉管进一步损伤，以及标的物识别试验表明，这些用新疫苗处理动物的行为恢复正常。
弗仑克尔博士认为，当这种方法用于人群试验时，也能阻止阿兹海默症和痴呆的健康水平下降。这种疫苗能用于表现有疾病的极早期症状的危机人群，以及对早已罹患中风的任何脉管损伤得以修复。迄今为止，这种疫苗在动物模型没有任何毒性。所有阿兹海默症中80%表明是血管性痴呆的患者，弗仑克尔博士希望这种新方法对后者能够治愈或者至少是一种有效治疗方法。
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